Document 0614
 DOCN  M9640614
 TI    An unclassified cerebral small cell tumor in a patient with human T-cell
       lymphotropic virus type 1-induced primary extranodal lymphoma.
 DT    9604
 AU    Komori T; Kasajima T; Yamamoto T; Shibata N; Kobayashi M; Department of
       Pathology, Tokyo Women's Medical College, Japan.
 SO    Mod Pathol. 1995 Oct;8(8):811-6. Unique Identifier : AIDSLINE
       MED/96117029
 AB    We describe an autopsy case of a thalamic tumor in a patient with human
       T-cell lymphotropic virus type 1 (HTLV-1)-induced extranodal lymphoma of
       the skull. Neither brain tumors associated with adult T-cell leukemia
       nor HTLV-1-induced extranodal lymphoma of bone have previously been
       reported. The tumor, which resembled an oligodendroglioma or
       dysembryoplastic neuroepithelial tumor, was composed of medium-sized
       cells with dark, round-to-polygonal nuclei and a mucinous matrix that
       formed pericellular lakes. Tumor cells were immunoreactive with S-100
       protein and neuron-specific enolase but not with glial fibrillary acid
       protein, synaptophysin, or vimentin. Tumor cells had prominent rough
       endoplasmic reticulum and free ribosomes with short processes,
       compatible with an oligodendroglial or small neuronal nature. Many
       atypical lymphocytes had infiltrated the leptomeningeal space,
       subependymal zone along the ventricular walls, fornices, corpus
       callosum, and right frontal lobe. Multinucleated or bizarre astrocytes
       and macrophages were found exclusively in the right frontal white
       matter. The coexistence of this unclassified peculiar brain tumor with
       bizarre astrocytosis suggests a cytopathic effect of HTLV-1 on human
       glioneuronal cells.
 DE    Adult  Astrocytes/PATHOLOGY  Brain Neoplasms/*PATHOLOGY  Case Report
       Human  Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated/*PATHOLOGY
       Male  Skull Neoplasms/*PATHOLOGY  Thalamus  JOURNAL ARTICLE

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